It is known that the regenerative properties of certain tissues and organs in mammals over time deteriorate. A long recovery from injury is one of the characteristic signs of aging. The reason for the loss of effective regeneration, as shown by previous studies, lies in the mitochondria — the centres of energy production necessary for cell activity. When the mitochondria do not work, stem cells are worse regeneration.
Scientists were able to restore the functioning of mitochondria in stem cells two year old mice with nicotinamide ribozid of substances similar in structure to vitamin B3 and are the predecessor of the coenzyme NAD . The latter serves as a carrier of electrons to metabolic chains in the mitochondria, due to which organelles produce energy in the form of ATP. As a result, the mice increased the regeneration of muscle tissue and they live longer than rodents that have not received ribozid.
Studies have demonstrated a similar effect on the stem cells of the brain and skin. No negative effects from the intake of nicotinamide ribozid even at high doses were observed, but scientists emphasize that there is a risk of activation of pathogenic cells, which can lead to the formation of malignant tumors.