"Everything that weakens the effectiveness of the Alliance, affects us, and if the EU starts to disintegrate, this will inevitably be a shock for NATO," said Hodges in an interview with bi-Bi-si.
In February NATO Secretary General Jens Stoltenberg also said the Alliance would have preferred that Britain remain in the EU.
According to General Hodges, Russia's actions exacerbated the immigration crisis, resulting in tens of thousands of people were forced to flee to Europe. Hodges said that Russia's aggression in Ukraine and the invasion in Syria have become a threat to European security.
Earlier, us General Philip Breedlove, the outgoing commander of NATO forces in Europe, also accused Russia that she deliberately helping the Syrian government in the creation of the refugee crisis, which uses as a weapon against Europe.
A referendum on membership of Britain in EU scheduled for June 23.